HPG Axis Sex Hormones and Mental Health
#testosterone #estrogen #anxiety #depression
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Gonadal hormones play a key role in the regulation of the hypothalamic–pituitary–adrenal (HPA) axis. By influencing the response and sensitivity to releasing factors, neurotransmitters, and hormones, gonadal steroids help orchestrate the gain of the HPA axis to fine-tune the levels of stress hormones in the general circulation
To increase survival and reproductive success, the HPA and the HPG axes work together to fine-tune each other thereby integrating environmental, psychological, reproductive, and genetic factors.
Gonadal hormones decrease as we age, in response to stress and even due to some medications or diabetes
The HPA and HPG axis both impact stress response
Chronic stress causes dysfunction in the HPA and HPG-Axes
Gonadal hormones alter levels of/sensitivity of dopamine, serotonin and GABA pre and postsynaptic receptors which directly correlate to alterations in mood and cognition
People need to be educated about
The impact of stress and cortisol on the HPA-Axis and HPG-Axis and consequently mood and energy
The impact of hormonal imbalances on stress tolerance, mood and cognition
Strategies to maximize their health and wellness
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